Active Skin Repair is a natural, non-toxic, non-sensitizing formula that is good for your skin and the planet. It is biodegradable and antibiotic free, so there is no risk of antibiotic resistance. There is also no risk of allergic reaction with this formula, so it's safe for even the most sensitive skin. It's also safe to use around the eyes, mouth, ears and nose. The main difference between the hydrogel and the spray is that the hydrogel uses a non-toxic biodegradable gel that helps moisturize damaged skin while the spray provides a light, liquid mist. They both use HOCl as the active ingredient, and can even be used together.